CECAM Workshop – Proteins in realistic environments: simulation meets experiment

Niels Hansen (Institute of Thermodynamics and Thermal Process Engineering, University of Stuttgart),  Jürgen Pleiss (Institute for Technical Biochemistry, University of Stuttgart), and Antje Spieß (Institute of Biochemical Engineering, Technical University of Braunschweig) organize the 3-day CECAM workshop Proteins in realistic environments: simulation meets experiment at the conference hotel campus.guest of Stuttgart University, Stuttgart, Germany (May 23-25 2018).

Proteins in a bioreactor or in a cell are solvated in a complex mixture of highly concentrated components which differs considerably from the dilute solutions of most in vitro and in silico studies. In realistic environment, the kinetics of an enzymatic reaction does not only depend on the chemical structure of the substrate and the enzyme, but is described by a multidimensional parameter space. It is a major challenge for experimentalists and for modelers to explore this huge parameter space, and strategies such as high-throughput experimentation, workflow system for parallel modeling, and statistical analysis or deep learning methods to reduce the dimensionality of parameter space, are highly desirable.

The goals of the workshop are to improve interaction and mutual understanding between the different worlds of modeling and experimentation, to provide an inspiring environment for creating innovative ideas and establishing new collaborations, and to pushing forward the molecular interpretation of experimentally obtained kinetic data.

Get more information and register online: https://www.cecam.org/workshop-0-1598.html