Microbioreactors research as front cover in Biotechnology and Bioengineering 2014

The journal Biotechnology and Bioengineering, one of the leading international journals in Biochemical Engineering has distinguished the investigations on the development of multiphase microbioreactors in the research consortium of ibvt, the Institutes for Surface Engineering and Microtechnology at the TU Braunschweig and the Institute de Microelectrónica de Barcelona within the DFG research group FOR 856 "Microsystems for particulate life science products (microPART)" with a picture on the cover of the September issue. The front cover shows rising microbubbles in the range of about 100 microns in diameter in a micro-bubble column reactor with a working volume of about 55 µL.
The contribution (Peterat et al. (2014), Characterization of oxygen transfer in vertical micro bubble columns for aerobic biotechnological screening Processes, Biotechnology and Bioengineering 111, 1809-1819) presents the applicability of a micro-fabricated bubble column reactor as a screening tool for aerobic cultivations. The rising bubbles induce a circulation of the liquid, so that the mixing by reducing the diffusion distance is improved and effectively prevent the sedimentation of cells to the reactor bottom. The active aeration of the micro device allows a flexible oxygen supply with mass transfer rates to 0.14 s-1. The applicability of the micro bubble column is shown for an aerobic submerged cultivation with the model organism Saccharomyces cerevisiae.